If your insulin resistant and eat a high carbohydrate (Glucose) meal this will create havoc with your metabolic system.1) You already have plenty of available glucose stored in your liver, your blood has excess glucose circulating that cannot enter your cells because of your level of insulin resistance.
2) You have Glut transporters that need to be brought to the surface of the cell to allow glucose entry into the cell. Insulin brings this Glut transporter to the cell surface. Because of your level of insulin resistance only a small portion of the glucose can enter the cells. The excess (leftover) glucose must be dealt with.
3) This excess glucose needs to be dealt with. Excess glucose is toxic to your cells and to the blood itself. This excess glucose is send to the liver. The liver is where fat production takes place. The liver converts this excess glucose to mainly saturated fat (C-16 Palmitic).
4) Fat like cholesterol does not mix with our water soluble blood. They both need to be bound to a carrier (Lipoprotein) for transport in the blood.
5) The human body has 2 distinct lipoprotein systems, one for dietary fat, one for liver made fat.
6) The lipoprotein made in the liver for the transport of this liver made fat is the lipoprotein VLDL, very low density lipoprotein. This lipoprotein VLDL key identifying protein is APOB100.
7) This VLDL eventually morphs into the small/dense Particle B lipoprotein. This causes most of your LDL cholesterol to become small/dense Particle B. These small/dense lipoprotein particles are small enough to penetrate the arterial wall ( Endothelium). These have the potential to be oxidized, you don`t want that.
8) **Oxidized cholesterol** accelerates the development of atherosclerosis.
9) You want your liver to make LDL cholesterol Particle A large and fluffy. Cholesterol is vital to every cell in your body and is the substrate needed to manufacture most of your hormones.
10) A T2 diabetic (insulin resistant) continues to eat a SAD high carbohydrate diet the excess glucose is send to the liver and the liver must make more of the lipoprotein VLDL. The more fat the liver makes from excess glucose (carbs) the more VLDL cholesterol it needs to make to transport the fat in the bloodstream.
11) If a T2 diabetic would be able to adopt a ketogenic diet and stop this excess flow of glucose to the liver his metabolic health would change dramatically.
12) Dietary fat can be used in place of glucose (Carbs) for most of your energy needs. Dietary fat is much more calorie dense than carbohydrate as fat has 9 calories per gram compared to 4 calories per gram of carbohydrate.
13) Dietary fat has a much different fate in the human body than liver made fat from excess glucose (carbs)
14) If you eat a ketogenic diet and are keto-adapted your cells can now use dietary fat (and your stored body fat) for direct energy.
15) Dietary fat has a totally different lipoprotein transport system that liver made fat, VLDL
16) Dietary fat is sent to your intestines (not the liver) where it is broken down into smaller units by your pancreatic digestive enzymes and re-packaged with the lipoprotein chylomicron. The protein identifier for chylomicron is different that the protein identifier for liver made fat. This protein identifier is APO48.
17) Your hungry cells quickly grab onto this chylomicron (APO48 identifier) and use this dietary fat for direct energy, if keto-adapted. These chylomicrons have a very short half life and these fats will be to few to measure in your fasting blood triglycerides.
18) Do not misunderstand me. I am *not* telling you to shove 2 sticks of butter down the hatch. Just like anything else in the human body you can only handle so much of anything at any given time. Your body has systems in place also for the flow of free fatty acids.
19) What am I trying to tell you with this information?
If your a T2 diabetic please stop eating a SAD high carbohydrate diet. Do not fear dietary fat, but do not use dietary fat as a new crutch for your over eating disorder