 Dietary and metabolic therapies have been attempted in a wide variety of neurological diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson disease, sleep disorders, brain cancer, autism, pain, and multiple sclerosis. The impetus for using various diets to treat – or at least ameliorate symptoms of – these disorders stems from both a lack of effectiveness of pharmacological therapies, and also the intrinsic appeal of implementing a more “natural” treatment. The enormous spectrum of pathophysiological mechanisms underlying the aforementioned diseases would suggest a degree of complexity that cannot be impacted universally by any single dietary treatment.
Yet, it is conceivable that alterations in certain dietary constituents could affect the course and impact the outcome of these brain disorders. Further, it is possible that a final common neurometabolic pathway might be influenced by a variety of dietary interventions. The most notable example of a dietary treatment with proven efficacy against a neurological condition is the high-fat, low-carbohydrate ketogenic diet (KD) used in patients with medically intractable epilepsy. While the mechanisms through which the KD works remain unclear, there is now compelling evidence that its efficacy is likely related to the normalization of aberrant energy metabolism. The concept that many neurological conditions are linked pathophysiologically to energy dysregulation could well provide a common research and experimental therapeutics platform, from which the course of several neurological diseases could be favorably influenced by dietary means. Here, National Center for Biotechnology Information provides an overview of studies using the KD in a wide panoply of neurologic disorders in which neuroprotection is an essential component NCBI: The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders Over the past decade, investigators have identified numerous mechanisms through which the KD may provide neuroprotective activity. Two hallmark features of KD treatment are the rise in ketone body production by the liver and a reduction in blood glucose levels. Ketone bodies themselves have been shown to possess neuroprotective properties, by raising ATP levels and reducing ROS production through enhanced NADH oxidation and inhibition of mitochondrial permeability transition. The second major biochemical feature of the KD is the decrease in glycolytic flux. Reduction of glycolysis is an essential feature of calorie restriction, which has been shown to suppress seizures, as well as prolong the lifespan of numerous species, including primates. More details: NCBI: The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
111 Comments
11/5/2022 07:17:02
Anything lose direction base billion federal second include. Commercial recognize safe reduce. Seek strategy about dark government edge. Name nothing begin size environmental. 8/25/2023 15:11:16
It turns out that even the hottest port has a few places where you can get off the beaten path. Here are some recommendations that will make you feel like you're in the know 2/24/2024 03:31:04
Impressed with Learn Quran Online USA's dedication to quality education! The user-friendly platform, experienced teachers, and comprehensive curriculum make it an ideal choice for Quranic learning. 2/24/2024 04:57:02
Highly impressed with my men's titanium wedding band! Its sleek design and hypoallergenic properties make it both stylish and practical. 2/27/2024 11:06:18
Exceptional service from Aeon Market Research Pvt Ltd! Their in-depth understanding of consumer behavior has helped us stay ahead of the competition. I'm blown away by Gomovies' exceptional service! Their website is a treasure trove of entertainment, with an extensive collection of movies and TV shows that caters to every taste. I love the convenience of their platform, which allows me to stream content seamlessly from any device. The streaming quality is top-notch, and I've never experienced any lag or buffering issues. Gomovies has truly raised the bar when it comes to online streaming! 4/17/2024 04:29:01
Kimcartoon is a treasure trove for cartoon lovers like me. Their website offers a vast collection of cartoons and animated series, ranging from classic favorites to the latest releases. I appreciate the user-friendly interface, which makes it easy to navigate and find the perfect show to watch. The streaming quality is excellent, and I've never encountered any buffering issues. Kimcartoon has become my go-to destination for nostalgic cartoon marathons and discovering new favorites. 5/18/2024 06:14:01
We stumbled over here by a different web page and thought I should check things out. I like what I see so now i’m following you. Look forward to looking over your web page yet again. 5/23/2024 01:54:44
Well done! I thank you your blog post to this matter. It has been useful. 6/8/2024 05:18:58
Good aftie, i am a blogger too. and i can see that you are a nice blogger too. 6/20/2024 03:57:55
Signal brouilleur de brouilleurpro est tout simplement exceptionnel. Les performances et la fiabilité de leurs appareils sont inégalées sur le marché. Pour ceux qui s’intéressent sérieusement au brouillage du signal, je recommande fortement d’explorer leurs offres. Cliquez ici pour voir plus de contenu de jam et rester informé des nouvelles versions. 6/28/2024 11:38:04
123movies is an excellent platform for streaming movies online. The variety of films available is extensive, ensuring there's always something new to watch. The video quality is top-notch, and the streaming is smooth without interruptions. The site is user-friendly, with a straightforward layout and efficient search options. It's incredible to have such a great resource available for free. Highly recommend 123movies for all your movie-watching needs. 7/4/2024 04:21:06
Partnering with venture capital for our tech startup was the best decision we made. The investors not only provided the necessary funds but also valuable mentorship and industry connections. This support has been crucial in navigating the competitive market and achieving our growth milestones. Highly recommend seeking venture capital for ambitious startups. 7/13/2024 01:33:18
Yes, I am agreed with this article and I just want to say that this article is very nice and very informative. I will make sure to be reading your blog more. You made a good point but I can't help but wonder, what about the other side? Thanks! We hired AE Bathrooms and Kitchens Fitters Ltd for a complete bathroom remodel, and they delivered outstanding results. The workmanship was top-notch, and they were very responsive to our needs and preferences. The project was completed on time, and the quality is exceptional. Truly a five-star service! 8/6/2024 04:29:58
I am not very excellent with English but I find this really easygoing to interpret . 8/26/2024 00:04:48
I recently purchased a mobile phone case, and I'm impressed with its quality and design. The case is both stylish and durable, offering excellent protection without adding bulk to my phone. The variety of designs available made it easy to find one that fits my personality perfectly! 8/29/2024 03:23:57
I just additional this particular feed to be able to my book marks. I need to say, I seriously take pleasure in reading your own sites. Keep it up! 9/4/2024 11:48:32
I intended to create you a little observation just to say thank you as before with the lovely techniques you’ve shown on this page. It was so surprisingly open-handed of people like you giving openly precisely what many of us might have sold as an electronic book to get some cash on their own, and in particular since you could possibly have tried it if you ever desired. These tactics as well worked to be the fantastic way to be aware that many people have the identical passion just like mine to grasp a lot more with regard to this matter. I know there are millions of more enjoyable situations ahead for individuals who see your blog post. 9/9/2024 02:57:13
Swatchseries Movies has been a game-changer for me! I love how quickly they upload new releases, and the streaming is smooth without any annoying interruptions. It’s perfect for movie nights or binge-watching sessions. 9/10/2024 13:36:18
The White Label SEO service we partnered with has allowed us to expand our service offerings without compromising quality. Their expertise in SEO is unmatched, and the ability to offer it as our own service has boosted our credibility and revenue. 9/11/2024 05:15:38
I had an amazing experience with the best dentist in Gurgaon. The professionalism and attention to detail were remarkable. They catered to my needs as an international patient, making the entire process smooth and hassle-free. Highly recommended for quality dental care! 9/20/2024 09:24:13
Have you ever considered adding more videos to your blog posts to keep the readers more entertained? I mean I just read through the entire article of yours and it was quite good but since I’m more of a visual learner,I found that to be more helpful well let me know how it turns out. 10/22/2024 04:30:27
I just couldn’t go away your website before suggesting that I actually loved the standard info a person supply on your guests? Is going to be again frequently to investigate cross-check new posts. 10/22/2024 12:26:54
Your article on the ketogenic diet as a treatment for various neurological disorders is both insightful and timely. The potential of the ketogenic diet (KD) to influence energy metabolism and provide neuroprotective effects is fascinating, especially given the complexity of conditions like epilepsy, Alzheimer's, and Parkinson's disease. It’s encouraging to see the increasing recognition of dietary approaches as complementary therapies, especially when pharmacological options may fall short. 10/23/2024 11:37:39
Was ich am meisten schätzte, waren die ausführlichen, leicht verständlichen Informationen zu Handy-Signalstörsendern. Egal, ob Sie gerade erst anfangen oder schon seit einiger Zeit recherchieren, dieser Inhalt ist klar und informativ. Ein großartiger Ort, um etwas über Störsender zu erfahren! 10/28/2024 05:13:52
We are grateful for your blog post. You will find a lot of approaches after visiting your post. I was exactly searching for. Thanks for such a post and please keep it up. Great work. 11/3/2024 01:49:33
Some really interesting details you have written. Aided me a lot, just what I was looking for : D. 11/3/2024 11:20:46
For luxurious yacht and limo rentals in Cyprus, turn to Cyprus VIP Service. We pride ourselves on delivering a truly VIP experience, paying close attention to each client's unique needs. Whether you're chartering a yacht or hiring a limousine, we ensure your journey is nothing short of extraordinary. 11/6/2024 01:30:59
This is a terrific post. Thanks for making the effort to summarize this all out for us. It is a great help!
Herbalife Cyprus is a worldwide nutrition company, with the target of helping people around the world to follow a healthy lifestyle. It produces high-quality products, well tested, which have become a favorite of all those who shared the same values as us and who aim to achieve the best version of themselves. Plenty of people have already succeeded and are maintaining their amazing results. We are committed to help and support you to achieve your desired result. 11/6/2024 22:49:41
Bringing you authentic puppy breeds like Toy Poodles, Maltese, and Pomeranians, we serve families all over Cyprus. Our team is known for being both friendly and trustworthy. 11/9/2024 01:05:04
I can’t really help but admire your blog, your blog is so adorable and nice “ 11/9/2024 07:04:13
I recently came across your website and have been reading along. I thought I would leave my first comment. I don’t know what to say except that I have enjoyed scaning what you all have to say 11/9/2024 12:08:35
These Gourmet Polkadot Chocolate Bars are next level! The flavor is unparalleled, and I trust the brand for authenticity and quality. 11/10/2024 10:46:15
Amazing experience! The suites are spacious and beautifully furnished, ideal for a luxury escape. Truly one of the best serviced suites in Larnaca. 11/11/2024 00:55:27
Hi, Can I export your page photo and utilize that on my webpage? 11/12/2024 03:19:46
I have been checking your blog site for any even though now, would seem like everyday I study some thing new Thanks 11/13/2024 01:42:12
F*ckin’ remarkable things here. I am very glad to see your post. Thanks a lot and i’m looking forward to contact you. Will you kindly drop me a e-mail? 11/14/2024 10:32:34
Himovies has become my go-to for free HD movies. The interface is user-friendly, and the streaming quality is consistently high. It’s perfect for movie marathons! 11/15/2024 03:03:50
What Happening i’m new to this, I stumbled upon this I’ve discovered It positively useful and it has helped me out loads. I’m hoping to give a contribution & aid other users like its helped me. Good job. 11/16/2024 00:04:14
Greetings, May I grab your page picture and implement it on my own blog page? 11/16/2024 00:43:54
After study many of the web sites for your website now, we genuinely much like your way of blogging. I bookmarked it to my bookmark website list and will also be checking back soon. Pls consider my internet site too and inform me what you think. 11/17/2024 08:34:27
I’ve been absent for some time, but now I remember why I used to love this blog. Thank you, I’ll try and check back more often. How frequently you update your web site? 11/17/2024 11:32:25
We had an amazing experience with the corporate leadership training. The trainer was engaging, and the strategies shared were practical and easy to implement. Highly recommend for any team looking to enhance leadership skills. 11/19/2024 00:57:30
Thanks for the points shared using your blog. Something else I would like to talk about is that weight reduction is not information about going on a dietary fad and trying to reduce as much weight that you can in a set period of time. The most effective way to burn fat is by having it slowly and gradually and obeying some basic ideas which can assist you to make the most from your attempt to shed weight. You may realize and already be following a few of these tips, nevertheless reinforcing knowledge never does any damage. 11/20/2024 03:09:00
Outsourcing to white label SEO was a game-changer. The professional service and seamless integration helped us scale and retain happy clients. 11/20/2024 03:51:13
I am constantly thought about this, thank you for putting up. 11/22/2024 10:07:37
Hello there, you web site is incredibly funny he informed me to cheer up .. Merry Christmas” 11/23/2024 04:08:30
Nice post. I discover some thing harder on distinct blogs everyday. Most commonly it is stimulating to see content from other writers and use something there. I’d opt to apply certain together with the content on my blog whether or not you don’t mind. Natually I’ll provide link on your own internet weblog. Many thanks for sharing. 11/24/2024 07:13:28
Awesome site! You’ve some very interesting posts.. Nice background as well haha. Continue the good work, Ill make sure to find to see really your page! 11/26/2024 22:38:25
Your blog is amazing dude. i love to visit it everyday. very nice layout and content “ 12/13/2024 10:39:17
Fryd Vape has impressed me with its quality and ease of use. The disposable design ensures hassle-free vaping anytime, anywhere. 12/15/2024 03:57:00
After I initially commented I clicked the -Notify me when new feedback are added- checkbox and now every time a remark is added I get four emails with the same comment. Is there any manner you may remove me from that service? Thanks! 12/15/2024 10:53:51
Hi. I want to ask a little something…is the following a wordpress web log as we are planning to be switching over to WP. Moreover did you make this template yourself? Thanks a lot. 12/19/2024 08:15:36
What I want to know is why I should care? I mean, not to say that what youve got to say isnt important, but I mean, its so generic. Everyones talking about this man. Give us something more, something that we can get behind so we can feel as passionately about it as you do. 12/22/2024 03:39:11
The banquet hall in New Delhi was perfect for our event! The Wazirpur location offered a stunning setup at an affordable price. 1/30/2025 03:16:54
Good day. i am doing research right now and your blog really helped me.
Hi I am so charmed I found your blog, I truly found you unintentionally, while I was watching on google for something different, Anyways I am here now and could simply prefer to state thank for a colossal post and an overall engaging site. Kindly keep up the incredible work. 2/4/2025 11:10:17
If you're looking for a great celebration hall in Jamia Nagar, this is the place! Well-maintained, affordable, and highly recommended. 2/23/2025 22:22:13
https://www.fiverr.com/awaiskhalidj 3/3/2025 10:05:00
Want to make extra money? I’ll show you a company where you can generate up to $875 per day—here’s everything you need to know to get started. 3/6/2025 10:41:51
Yamuna Banquet Hall in Kalindi Kunj exceeded my expectations! Elegant setup, friendly staff, and delicious catering options. 3/11/2025 11:03:34
As a Newbie, I am continuously exploring online for articles that can help me. Thank you 3/13/2025 01:00:59
Absolutely love these lip glosses! They glide on smoothly, last long, and add a beautiful glossy finish to my lips! 3/15/2025 11:28:51
Very well-done blog. I especially appreciate content that has to do with health and fitness, so it’s refreshing to me to see what you have here. Keep it up! facial exercises 3/20/2025 11:18:46
I’d constantly want to be update on new blog posts on this internet site , saved to favorites. 3/28/2025 04:03:06
Great article with excellent idea!Thank you for such a valuable article. I really appreciate for this great information.. 3/29/2025 07:44:14
I like what you guys are up too. Such smart work and reporting! Carry on the superb works guys I’ve incorporated you guys to my blogroll. I think it will improve the value of my web site . 3/30/2025 02:20:21
Youre so cool! I dont suppose Ive learn something like this before. So nice to find any individual with some authentic thoughts on this subject. realy thanks for beginning this up. this web site is one thing that is wanted on the internet, somebody with a bit originality. useful job for bringing something new to the internet! 4/3/2025 04:50:54
I've been searching for data on this theme for some time. I'm glad this one is so extraordinary. Keep up the superb work 4/6/2025 09:49:37
Thanks for sharing, it is a great inspirational thread to will motivate many people to work on new things. 4/9/2025 00:28:58
I booked a conference hall in South Delhi for our corporate event—great location, well-equipped facilities, and professional staff. Everything ran smoothly! 4/10/2025 04:23:33
I am extremely impressed along with your writing talents as smartly with the structure for your blog. Is this a paid topic or did you modify it yourself? Either way stay up the excellent quality writing, it is rare to peer a nice blog like this one nowadays.. 4/13/2025 12:46:35
You got a very great website, Glad I discovered it through yahoo. 4/17/2025 05:46:03
Happy to visit your blog, I am by all accounts forward to more dependable articles and I figure we as a whole wish to thank so numerous great articles, blog to impart to us. 4/22/2025 01:42:36
Fast, friendly, and professional cash home buyers in Chestermere and surrounding areas. A lifesaver when time is tight! 4/26/2025 00:42:19
I am really loving the theme/design of your weblog. Do you ever run into any browser compatibility problems? A handful of my blog visitors have complained about my site not working correctly in Explorer but looks great in Chrome. Do you have any solutions to help fix this problem? 4/27/2025 00:28:04
A formidable share, I just given this onto a colleague who was doing a bit of evaluation on this. And he actually bought me breakfast as a result of I found it for him.. smile. So let me reword that: Thnx for the treat! However yeah Thnkx for spending the time to discuss this, I really feel strongly about it and love studying extra on this topic. If doable, as you develop into experience, would you thoughts updating your blog with more particulars? It is highly helpful for me. Huge thumb up for this weblog publish! 4/28/2025 00:40:51
I recently came across your website and have been reading along. I thought I would leave my first comment. I don’t know what to say except that I have enjoyed scaning what you all have to say 5/3/2025 01:01:37
What are you saying, man? I realize everyones got their own view, but really? Listen, your blog is neat. I like the energy you put into it, specially with the vids and the pics. But, come on. Theres gotta be a better way to say this, a way that doesnt make it seem like everyone here is stupid! 5/4/2025 02:03:37
Thank you for sharing excellent information. Your web-site is so cool. I’m impressed by the info that you’ve on this website. It reveals how nicely you perceive this subject. Bookmarked this web page, will come back for more articles. 5/5/2025 01:05:58
Fabulous piece,I do believe you’ve definitely designed a web site I have to come back to daily. Keep it up. You lost me, friend. I am talking about, I imagine I am what youre saying. I am aware what you’re saying, and you just seem to have forgotten that might be other folks in the world who view this issue for it is actually and may perhaps not concur with you. You may well be turning away a whole lot of folks who might have been lovers of your website. 5/19/2025 23:53:49
Thanks for sharing your ideas. I would also like to say that video games have been actually evolving. Technology advances and improvements have aided create reasonable and interactive games. These kind of entertainment video games were not actually sensible when the real concept was first of all being used. Just like other forms of technologies, video games as well have had to grow by means of many many years. This itself is testimony for the fast continuing development of video games. 6/10/2025 01:19:00
hi!,I like your writing so much! share we communicate more about your post on AOL? I need an expert on this area to solve my problem. Maybe that’s you! Looking forward to see you. 6/10/2025 12:02:08
Prevalent post, keep up with this astounding work. It's ideal to realize that this subject is by and large moreover secured on this web website so supports setting aside the effort to audit this! Much appreciated again just as once more! 6/19/2025 01:54:10
please visit the sites we follow, including this one, as it represents our picks from the web 6/21/2025 03:59:49
Nice to be visiting your blog again, it has been months for me. Well this article that i've been waited for so long. I need this article to complete my assignment in the college, and it has same topic with your article. Thanks, great share. 6/22/2025 00:45:12
Hey There. I found your blog using msn. This is an extremely well written article. I will be sure to bookmark it and return to read more of your useful information. Thanks for the post. I will certainly return. 6/29/2025 02:14:45
I’m curious to find out what blog system you happen to be working with? I’m having some minor security problems with my latest site and I would like to find something more risk-free. Do you have any solutions? 6/30/2025 00:48:19
Con Puff 25000 ho scoperto un mix perfetto tra quantità e qualità. Il gusto resta forte fino alla fine. 6/30/2025 23:34:45
Just where perhaps you have discovered the source for the purpose of that write-up? Wonderful studying I have subscribed to your feed. 7/2/2025 02:19:29
It’s rare knowledgeable men and women with this topic, however, you seem like do you know what you’re speaking about! Thanks 7/3/2025 00:50:25
One of the best Muslim marriage halls in South Delhi—elegant setup, spacious interiors, and perfect for traditional ceremonies. Leave a Reply. |
RSS Feed
