It appears evident that the Endocannabinoid system is the Master control system for fine tuning all of our major body systems (immune, gastrointestinal, neurologic, metabolic) including the endocrine. There is evidence in the literature of dysfunction or involvement of the Endocannabinoid system in all endocrine functions and more broadly into metabolism. There is extensive literature and research into the ovarian, pancreas, adrenal, thyroid, hypothalamus – pituitary – adrenal system as well as the neural hormones. It appears that, in overview, the Endocannabinoid receptors are used to stimulate and inhibit endocrine function at a cellular level. In light of this all of endocrinology needs to be reorganized to incorporate a full understanding of the role of the Endocannabinoid system in modulating the endocrine subsystem.
1. CBD is a normalizing substance that restores homeostasis. The medical literature has identified over 30 mechanisms cannabidiol has used in modulating a particular physiologic function only a few of which were part of the Endocannabinoid system. CBD appears to correct for a a dysfunctional Endocannabinoid system and restore inter-and intracellular signaling. With those systems restored supplemental hormones could be more effective in individuals more responsive to smaller doses and less specific hormone combinations.
2. CBD does restore some function, inter and intracellular signaling and protects endocrine cells from further damage by oxidative substances as well as autoimmune disorders. There is suggestion in the literature for a regeneration of some endocrine cells, pancreatic beta cells for example but no evidence at this time.
Let me give you an interesting example in that between 10 and 20% of men and women develop increased libido while taking cannabidiol. This even occurs with some geriatric patients over the age of 70. None of these behaviors appear to be extreme or outside of the physiologic range of normal. More accurately it could be described as a restoration of normal human behavior and function. At no time have I seen any abnormal or extreme behaviors or endocrine function.
Philip Blair MD
Medical Director for Elixinol, LLC